Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue
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چکیده
منابع مشابه
Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat.
We examined the effect of dietary fats rich in n-3 polyunsaturated fatty acids (PUFA) on mRNA levels in white and brown adipose tissues in rats. Four groups of rats were fed on a low-fat diet (20 g safflower oil/kg) or a high-fat diet (200 g/kg) containing safflower oil, which is rich in n-6 PUFA (linoleic acid), or perilla (alpha-linolenic acid) or fish oil (eicosapentaenoic and docosahexaenoi...
متن کاملA 211-bp enhancer of the rat uncoupling protein-1 (UCP-1) gene controls specific and regulated expression in brown adipose tissue.
The uncoupling protein-1 gene is uniquely expressed in brown adipose tissue (BAT) and is positively regulated by cold exposure of animals and the sympathetic nervous system. To analyse the importance of a previously identified 211-bp enhancer [Cassard-Doulcier, Gelly, Fox, Schrementi, Raimbault, Klaus, Forest, Bouillaud and Ricquier (1993) Mol. Endocrinol. 7, 497-506] in the tissue-specific exp...
متن کاملCold-induced alterations of phospholipid fatty acyl composition in brown adipose tissue mitochondria are independent of uncoupling protein-1.
The recruitment process induced by acclimation of mammals to cold includes a marked alteration in the acyl composition of the phospholipids of mitochondria from brown adipose tissue: increases in 18:0, 18:2(n-6), and 20:4(n-6) and decreases in 16:0, 16:1, 18:1, and 22:6(n-3). A basic question is whether these alterations are caused by changes in the concentration of uncoupling protein-1 (UCP1) ...
متن کاملUncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria.
In thermogenic brown adipose tissue, uncoupling protein 1 (UCP1) catalyzes the dissipation of mitochondrial proton motive force as heat. In a cellular environment of high oxidative capacity such as brown adipose tissue (BAT), mitochondrial uncoupling could also reduce deleterious reactive oxygen species, but the specific involvement of UCP1 in this process is disputed. By comparing brown adipos...
متن کاملUncoupling protein 1 controls reactive oxygen species in brown adipose tissue.
Brown adipose tissue (BAT) is an organ specialized to fuel nonshivering thermogenesis for the defense of high body temperature of many eutherian mammals in the cold. Cold-induced sympathetic stimulation of brown adipocytes activates lipolysis, glucose uptake, and mitochondrial biogenesis, with the mitochondrial biogenesis providing a powerful cellular engine for heat generation. At the mitochon...
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ژورنال
عنوان ژورنال: British Journal of Nutrition
سال: 2018
ISSN: 0007-1145,1475-2662
DOI: 10.1017/s0007114518001629